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Gene Therapy Market Size to Worth Around US$ 15.0 Billion by 2030

The global Gene Therapy market size is expected to be worth around US$ 15.0 billion by 2030, according to a new report by Vision Research Reports.

The global Gene Therapy market size was valued at US$ 2.30 billion in 2020 and is anticipated to grow at a CAGR of 20.8% during forecast period 2021 to 2030.

What are the market growth factors?

The market growth is attributed to the increasing prevalence of cancer coupled with the lack of effective treatment for the disease. Constant expansion of cancer genetic studies has deciphered relevant information about cancer-related molecular signatures.

This has driven the for advanced cancer therapeutics, thereby driving the market growth. In addition, expansion of this mode of treatment in non-cancer applications with approval of therapies, such as approval of Bluebird Bio’s Zynteglo in June 2019 for β-thalassemia and others, demonstrates the shift in the preferences of companies towards other unsaturated segments.

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Various universities and institutes are observed to exhibit a broad portfolio in the pipeline, which is anticipated to boost revenue generation in the future. The market is anticipated to witnesses a short-term revenue slowdown due to a shift in focus and delay in product launches. However, initiatives for developing novel trial designs, improving the regulatory environment, and managing the supply chain are expected to play a critical role in minimizing the impact of the current global crisis.

Report Highlights

Spinal Muscular Atrophy (SMA) led the gene therapy market in 2020 with the highest revenue share of over 41%. However, the large B-cell lymphoma segment is estimated to account for the maximum revenue share by 2028. Although Spinal Muscular Atrophy (SMA) is a rare disease, it is one of the most common fatal inherited diseases of infancy. The development of gene therapy, Zolgensma (AVXS-101), has significantly proven its efficiency in the treatment of SMA, along with changing the disease phenotype. In May 2019, Novartis received approval from the U.S. FDA for Zolgensma, which is designed to address the root cause of SMA. Zolgensma is the first and only approved gene therapy in this segment.

Novartis and Gilead continue to expand their customer base across the globe for Kymriah and Yescarta, which are designed for the treatment of large B-cell lymphoma. Recently, in May 2019, Novartis received approval to sell its products in Japan. Moreover, as per the investigation, in 2017, around 51% of patients who received Yescarta treatment achieved remission. Furthermore, Kite Pharma introduced a team for providing training about logistical and biological intricacies for the drug to hospitals and clinics that will be using Yescarta, thereby driving the segment growth.

The AAV segment led the global market in 2020 and held the largest market share of over 43% as a result of the success of AAV-based Zolgensma. In recent times, usage of AAV is rising significantly across various therapeutic areas, consequently witnessing a considerable demand during the forecast years. Proven records of non-pathogenicity is one of the important key factors boosting their adoption.

Companies, such as Dimension Therapeutics, AGTC, Spark Therapeutics, Sangamo Biosciences, Biogen, and AveXis, are involved in the AAV viral vector-based gene therapy R&D. On the other hand, lentiviruses are anticipated to emerge as the fastest-growing vector type segment from 2021 to 2028. This can be attributed to the rising investments by companies and research institutes in this vector type, post-approval of Zynteglo in 2019 and Kymriah in 2017.

Furthermore, the presence of companies that offer exclusive lentivector platform is accelerating revenue growth in this segment. For instance, Oxford Biomedica Plc has an exclusive lentivector platform, an advanced and safe gene delivery system that can carry payloads of up to 9kb and is capable of permanent modification of dividing and nondividing cells along with no pre-existing immunity.

The North America regional market led the industry in 2020 with a revenue share of more than 55% and will grow further at the fastest CAGR over the forecast years. On account of a strong regulatory framework for promoting the development of cellular therapy and the presence of a substantial number of biopharma companies, several government agencies are investing in the region. This, in turn, is driving the growth of the regional market.

The presence of centers and institutes engaged in R&D on gene therapies is likely to continue driving the market in North America. Several companies from regions, such as Europe, which have received EU approvals, are planning to receive FDA approvals over. For example, post-EU approval of bluebird Bio’s Zynteglo (formerly LentiGlobin) in June 2019, the company is planning to file for an FDA approval.

On the other hand, Zolgensma’s approval in 2019 has greatly favored the U.S. market. Despite the price controversies, the product managed to witness lucrative revenue growth in the year 2020. These factors are anticipated to maintain the dominance of this region in the global market during the forecast period.

Key Players

  • REGENXBIO, Inc.
  • Oxford BioMedica plc
  • Dimension Therapeutics, Inc.
  • Bristol-Myers Squibb Company
  • SANOFI
  • Applied Genetic Technologies Corporation
  • F. Hoffmann-La Roche Ltd.
  • Bluebird Bio, Inc.
  • Novartis AG
  • Taxus Cardium Pharmaceuticals Group, Inc. (Gene Biotherapeutics)
  • UniQure N.V.
  • Shire Plc
  • Cellectis S.A.
  • Sangamo Therapeutics, Inc.
  • Orchard Therapeutics
  • Gilead Lifesciences, Inc.
  • Benitec Biopharma Ltd.
  • Sibiono GeneTech Co., Ltd.
  • Shanghai Sunway Biotech Co., Ltd.
  • Gensight Biologics S.A.
  • Transgene
  • Calimmune, Inc.
  • Epeius Biotechnologies Corp.
  • Astellas Pharma, Inc.
  • American Gene Technologies
  • BioMarin Pharmaceuticals, Inc.

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Market Segmentation

  • Indication Outlook
    • Acute Lymphoblastic Leukemia (ALL)
    • Inherited Retinal Disease
    • Large B-cell Lymphoma
    • ADA-SCID
    • Melanoma (lesions)
    • Beta-Thalassemia Major/SCD
    • Head & Neck Squamous Cell Carcinoma
    • Peripheral Arterial Disease
    • Spinal Muscular Atrophy (SMA)
    • Others
  • Vector Type Outlook
    • Lentivirus
    • AAV
    • Retrovirus & gamma Retrovirus
    • Modified Herpes Simplex Virus
    • Adenovirus
    • Non-viral Plasmid Vector
  • Regional Outlook 
    • North America
      • U.S.
      • Canada
    • Europe
    • Asia Pacific
      • Japan
      • China
      • Russia
      • Australia
    • Rest of the World

The Gene Therapy market research report covers definition, classification, product classification, product application, development trend, product technology, competitive landscape, industrial chain structure, industry overview, national policy and planning analysis of the industry, the latest dynamic analysis, etc., and also includes major. The study includes drivers and restraints of the global market. It covers the impact of these drivers and restraints on the demand during the forecast period. The report also highlights opportunities in the market at the global level.

The report provides size (in terms of volume and value) of Gene Therapy market for the base year 2020 and the forecast between 2021 and 2030. Market numbers have been estimated based on form and application. Market size and forecast for each application segment have been provided for the global and regional market.

This report focuses on the global Gene Therapy market status, future forecast, growth opportunity, key market and key players. The study objectives are to present the Gene Therapy market development in United States, Europe and China.

It is pertinent to consider that in a volatile global economy, we haven’t just conducted Gene Therapy market forecasts in terms of CAGR, but also studied the market based on key parameters, including Year-on-Year (Y-o-Y) growth, to comprehend the certainty of the market and to find and present the lucrative opportunities in market.

In terms of production side, this report researches the Gene Therapy capacity, production, value, ex-factory price, growth rate, market share for major manufacturers, regions (or countries) and type.

In terms of consumption side, this report focuses on the consumption of Gene Therapy by regions (countries) and application.

Buyers of the report will have access to verified market figures, including global market size in terms of revenue and volume. As part of production analysis, the authors of the report have provided reliable estimations and calculations for global revenue and volume by Type segment of the global Gene Therapy market. These figures have been provided in terms of both revenue and volume for the period 2017 to 2030. Additionally, the report provides accurate figures for production by region in terms of revenue as well as volume for the same period. The report also includes production capacity statistics for the same period.

With regard to production bases and technologies, the research in this report covers the production time, base distribution, technical parameters, research and development trends, technology sources, and sources of raw materials of major Gene Therapy market companies.

Regarding the analysis of the industry chain, the research of this report covers the raw materials and equipment of Gene Therapy market upstream, downstream customers, marketing channels, industry development trends and investment strategy recommendations. The more specific analysis also includes the main application areas of market and consumption, major regions and Consumption, major Chinese producers, distributors, raw material suppliers, equipment providers and their contact information, industry chain relationship analysis.

The research in this report also includes product parameters, production process, cost structure, and data information classified by region, technology and application. Finally, the paper model new project SWOT analysis and investment feasibility study of the case model.

Overall, this is an in-depth research report specifically for the Gene Therapy industry. The research center uses an objective and fair way...

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