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Heat stress and fatty liver hemorrhagic syndrome in poultry

Heat stress and fatty liver hemorrhagic syndrome in poultry

The liver is a key organ for the health and productivity of poultry and plays a significant part in the digestion, metabolism and utilization of nutrients.

The liver is involved in the metabolism of fats, carbohydrates and proteins; it is the main storage site for fat-soluble vitamins (A, D, E and K), the water-soluble vitamin B12, glycogen, iron and copper; it is involved in the activation of vitamin D; plays a major role in the detoxification of microbial and chemical toxins; provides important circulatory proteins such as albumin and clotting factors; and secretes bile for the digestion of fats.

The liver and fat metabolism in poultry

In birds, unlike mammals, fat synthesis occurs mainly in the liver and the adipose tissues distributed through the body serve only to store fats.

Once synthetized in the liver, fats are transported by very low density lipoproteins (VLDL) to the adipose tissues in the form of plasma triglycerides (TG). Whenever the synthesis of fat in the liver increases, the transport of TG by VLDL to the adipose tissues surges, but when the production of VLDL is no longer sufficient to transport all the TG synthesized by the liver, the leftover lipids accumulate and result in hepatic steatosis or fatty liver disease.

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Fatty Liver Disease

Fatty liver disease, also called fatty liver syndrome, fatty liver hemorrhagic syndrome, hepatic steatosis and hepatic lipidosis, is a fairly common disease found mainly in laying chicken, ducks, geese and turkeys. The liver of the affected birds accumulates fat, killing the hepatocytes (liver cells) and replacing them with scar tissue.

Unspecific signs include reduced appetite, abnormal feather color, lethargy, difficulties in breathing, pale combs, greenish or yellowish diarrhea due to excess bilirubin or biliverdin, and death. In laying and breeding hens, the laying rate drops, skeletal problems appear and eggshells become fragile due to alterations in the calcium metabolism.

Specific signs include an enlarged or distended abdomen due to the abnormal size of the liver, to secondary ascites or to fat accumulation. More than 20% of the animals are overweight.

On necropsy, the liver is enlarged, engorged with fat, friable and hemorrhagic. The number of haemorrhages found in the liver help to determine the severity of the disease, through the “fatty liver syndrome score” (from 1, no haemorrhage to 5, more than 25 haemorrhages).

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The liver may be also pale, greasy and soft, but paleness is not a specific sign of the disease.

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Heat stress and fatty liver disease

The incidence of fatty liver disease increases during the hot season. Experimentally, it has been demonstrated that broilers exposed to heat stress for two weeks show a higher concentration of triglycerides and enzymes related to lipid synthesis in their livers and that after three weeks their liver cells suffer from fatty degeneration.

Nutritional factors associated to fatty liver disease in heat stressed birds

High environmental temperatures, together with the lethargy produced by heat stress, reduce the energy requirements of the animals. The energy left over from what the bird has consumed through the diet is transformed into fats in the liver, where they accumulate and start the fatty liver disease.

As we discussed above, fats are transported to adipose tissues located to other parts of the body, in example the abdomen. The deposit of abdominal fat worsens the negative effects of heat stress, because it interferes with normal breathing and cooling.

Metabolic factors associated to fatty liver disease in heat stressed birds

There is evidence that heat stress produces a severe unbalance in the metabolism of the liver, including increased synthesis of glycogen, glucose, antioxidants such as glutathione, damage to the membranes of the hepatocytes, and a slower cell regeneration cycle.

When it comes to lipid metabolism in the liver, heat stress induces lipogenesis (synthesis of lipids) and inhibits lipolysis (breaking down of fats), leading to accumulation of fats. The metabolic pathways through which these disorders occur are still under investigation, but, in example:

  • It has been suggested that the induction of lipogenesis happens through the activation of the liver X receptor (LXR) pathway, a receptor involved in the regulation of cholesterol, fats and glucose.
  • It has been hypothesized that the neuropeptide orexin, involved in the regulation of appetite and in the break down of fats, is less expressed in animals affected by heat stress.
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Prevention of fatty liver disease during periods of heat stress with certain nutrients and phytogenics

Vitamin E to enhance general liver health

Vitamin E is one of the most potent antioxidants in nature. It plays a key role in neutralizing free radicals or reactive oxygen species (ROS), as we discussed in this post.

The biological activity of vitamin E is not limited to its antioxidant properties: it is involved in the regulation of the following processes: inflammatory response, gene expression, certain enzymes, cellular signaling, and cell proliferation.

During fatty liver disease, the administration of vitamin E reduces the deposits of fats in the hepatocytes, ameliorates inflammation and fibrosis and activates certain beneficial metabolic processes in the liver.

Our products PhytoMax© and PlusBreathe© contain vitamin E.

Selenium and zinc

Birds with zinc and/or selenium deficiencies are more susceptible to fatty liver disease.

On the other hand, the administration of zinc and selenium helps to prevent the onset of the hepatic steatosis and to reduce the damaging effects once...

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